Products / Supplement
Vitamin D3 with Vitamin K2 (MK-7)
Vitamin D3 (cholecalciferol) supplemented alongside Vitamin K2 as menaquinone-7 (MK-7). Suited to patients with low Vitamin D identified on a blood test.
Suitability and pricing are confirmed with your clinician at review.
About this product
Vitamin D deficiency and insufficiency are common in the UK across the year and the standard supplement to correct it is cholecalciferol (D3), the same form the skin produces from sunlight. NICE CKS Vitamin D deficiency in adults defines serum 25-OH vitamin D below 25 nmol/L as deficient and 25 to 50 nmol/L as insufficient, with cholecalciferol 800 to 1,000 IU (20 to 25 micrograms) daily as the maintenance dose following loading, or as the starting dose for insufficiency. Higher loading doses (typically up to 4,000 IU daily or 50,000 IU weekly for a short course) are used under clinician guidance for established deficiency. Pairing D3 with Vitamin K2 as MK-7 supports the routing of the calcium that D3 helps absorb, directing it toward bone and away from soft tissue and arterial walls. The MK-7 form of Vitamin K2 has a longer half-life than MK-4 and is the form most commonly used in clinical and supplement settings. Important safety note: Vitamin K2 antagonises warfarin and other coumarin anticoagulants and should not be started without specialist review if you are on these medicines. High-dose cholecalciferol should be discussed with your clinician before starting if you have hypercalcaemia or hypercalciuria, sarcoidosis or other granulomatous disease (such as tuberculosis or lymphoma), primary hyperparathyroidism, a history of calcium-containing kidney stones, or severe kidney impairment, because vitamin D can raise calcium levels and trigger hypercalcaemia in these conditions.
How it works
Vitamin D3 (cholecalciferol) is converted by the liver to 25-hydroxyvitamin D (the form measured on a blood test) and then by the kidneys to its active form, calcitriol. Calcitriol regulates calcium and phosphate metabolism, supports immune function, and influences a wide range of other tissues. Vitamin K2 (MK-7) activates osteocalcin and matrix Gla-protein, which direct calcium to bone and inhibit its deposition in soft tissue.
Who this product is for
- Your blood test has shown low or insufficient Vitamin D (typically below 50 nmol/L)
- You have limited sun exposure, work indoors, or live at a northern latitude
- You are dark-skinned or wear covering clothing (groups at higher risk of deficiency)
- You want a single-purpose Vitamin D supplement rather than a multivitamin
Active ingredients
- · Vitamin D3 (cholecalciferol)
- · Vitamin K2 as menaquinone-7 (MK-7)
Linked blood markers
This supplement is most useful when paired with a blood test result. Read the clinical context for each linked marker on WMG Healthcare:
Important information
This supplement is not a prescription medication and is sold for general health use under clinician guidance. It is not a substitute for diagnosis or treatment. If you have a chronic medical condition, take prescribed medications, are pregnant or breastfeeding, or are under 18, speak to a clinician before starting a new supplement.
If you experience side effects or have any clinical concerns, contact us via the enquiry form or call 020 3239 3378. For urgent symptoms please contact your GP, NHS 111, or 999.
Other supplements
Compare against the rest of the range.